Department of Chemical & Biological Sciences

Head of Department

Dr. Amit Kumar Paul
Ph.D, IACS, University of Calcutta

E-mail:
hod.cy@nitm.ac.in

Faculty

Back

Dr. Atanu Singha Roy Associate Professor

B.Sc.: University of Calcutta (RKM Vidyamandira); M.Sc. & Ph.D. (IIT Kharagpur)

asroy86@nitm.ac.in; singharoyatanu@gmail.com
9402102387
https://nitmeghalaya.irins.org/profile/113569

Research Interest

Biophysical Chemistry, Protein-Ligand Interaction Studies Using Biophysical Techniques, Biomolecular Spectroscopy,Protein Denaturation Studies, DNA-Ligand binding and DNA Damaging Experiments, Protein modification and impact on ligand biding, Protein-nano particle interaction, Quantum Dots and their biological applications.

Education Qualification

B.Sc.: University of Calcutta (RKM Vidyamandira); M.Sc. & Ph.D. (IIT Kharagpur)

Group Homepage

Work Experience

  • Assistant Professor, Department of Chemistry (July 22, 2013-July 21, 2015), Lovely Professional University, Punjab 144411
  • Assistant Professor, Department of Chemistry (July 23, 2015-December 20, 2023), NIT Meghalaya.

Courses Taught

B.Tech. Courses

  •    ES 101/CY 102: Environmental Science (with Dr. Naba Kamal Nath)  
  •    CH 101: Engineering Chemistry (with Dr. Mukul Pradhan)  

   

   M.Sc. Chemistry Courses

  •    CH 403: Physical Chemistry I
  •    CH 407: Physical Chemistry II
  •    CH 408/CY 408: Molecular Spectroscopy 
  •    CY 410: Surfaces and Electrochemistry
  •    CY 533: Biochemistry and Medicinal Chemistry
  •    CY 581: Physical Chemistry Laboratory
  •    CY 405: Chemical and Statistical Thermodynamics 
  •    CY 484: Analytical Chemistry Laboratory

Publications

International Journals:

Submitted Articles

    • 65. S. Quraishi et al., Elucidation of inhibitory effects of bioactive anthraquinones towards formation of DNA advanced glycation end products (DNA-AGEs) [ACS Food Sci. Technol.]
    • 64. A. Mondal et al., A Protein-Based Self-healing Hydrogel for Prolonged Antimicrobial Drug Delivery with Synergistic Activity [New J. Chem.]
    • 63. M. Haque et al., Human Serum Albumin Directed Formation of Cadmium Telluride Quantum Dots: Applications in Biosensing, Anti-bacterial Activities and Cell Cytotoxicity Measurements [Int. J. Biol. Macromol.]
    • 62. G. Kalita, Paresh Nath Chatterjee et al., Deciphering the Intriguing Molecular Recognition of a Novel Indene-Phloroglucinol Tethered Compound with Human Serum Albumin Using Multi-Spectroscopy and Molecular Docking Studies [Journal of Molecular Structure]

Publications from NIT Meghalaya 

61. K. Baruah et al., Interactions of Turmeric and Curcumin Functionalized Gold Nanoparticles with Human Serum Albumin: Exploration of protein-corona formation, Binding Thermodynamics and anti-fibrillation studies [Langmuir, Accepted]

60. S. Sarmah et al., Synthesis and structural characterization of chrysin-Cu(II) complex: In vitro investigation into the DNA/protein binding, cell cytotoxicity and radical scavenging properties [Journal of Biomolecular Structure and Dynamics, Accepted].

59. Sana Quraishi, Debanjan Saha, Kalpana Kumari, Anupam Nath Jha*, Atanu Singha Roy,*Non-covalent binding interaction of bioactive coumarin esculetin with calf thymus DNA and yeast transfer RNA: A detailed investigation to decipher the binding affinities, binding location, interacting forces and structural alterations at a molecular level, International Journal of Biological Macromolecules (just accepted), 2023. [Q1]

58. Nudrat, Sadia; Maity, Sankar; Khare, Shivam; Kumari, Kalpana; Jana, Madhurima; Roy, Atanu Singha, Construing the interactions of coumarin derivatives with the main protease of stomach pepsin using spectroscopic and computational analyses: insights into the binding thermodynamics, anti-fibrillation studies and enzymatic assay, ACS Food Science and Technology (just accepted), 2023. [Q2]

    57. Sona Lyndem, Upasana Hazarika, Anindita Bhatta, Vivek Prakash, Anupam Nath Jha*, Atanu Singha Roy*, In-vitro Interactions of Esculin and Esculetin with Bovine Hemoglobin Alter its Structure and Inhibit Aggregation: Insights from Spectroscopic and Computational Studies, New Journal of Chemistry, 2023 (Advance Article) [Q2].

    56. Sadia Nudrat, Piyusaranjan Giri, Dasuklang Lyngdoh Nongbri, Kalpana Kumari, Sana Quraishi, Madhurima Jana*, Kripamoy Aguan, Atanu Singha Roy*, Analysis of the Binding Mechanism of Bioactive Coumarins with Ovalbumin: Further Investigation into the Inhibitory Effects toward Protein Fibrillation, ACS Food Science and Technology, 2023, 3, 5, 866–880. [Q2]

    55. Mahabul Haque, Ibemhanbi Konthoujam, Sona Lyndem, Sudipta Koley, Kripamoy Aguan, Atanu Singha Roy*Formation of ZnS Quantum Dots using Green Tea Extract: Applications into Protein binding, Bio-sensing, Anti-bacterial and Cell Cytotoxicity studies, Journal of Materials Chemistry B2023,11, 1998-2015. [Q1]

    54. Kakali Baruah, Ibemhanbi Konthoujam, Sona Lyndem, Kripamoy Aguan, Atanu Singha Roy*Complexation of turmeric and curcumin mediated silver nanoparticles with human serum albumin: Further investigation into the protein-corona formation, anti-bacterial effects and cell cytotoxicity studies, Spectrochimica Acta A: Molecular and Biomolecular Spectroscopy, 294, 2023, 122540. [Q2]

    53. Sona Lyndem, Upasana Hazarika, P Athul, Anindita Bhatta, Vivek Prakash, Anupam Nath Jha*, Atanu Singha Roy*A comprehensive in vitro exploration into the interaction mechanism of coumarin derivatives with bovine hemoglobin: Spectroscopic and computational methods, Journal of Photochemistry and Photobiology A: Chemistry, 436, 2023, 114425. [Q2]

    52 .S. Sarmah, U. Hazarika, Sony Moni Das, Sana Quraishi, Anindita Bhatta, Vinay Kumar Belwal, Anupam Nath Jha*and Atanu Singha Roy*, Deciphering the interactions of phytochemicals with ovalbumin, the major food allergen from egg-white: Spectroscopic and computational studies, Luminescence, (Just Accepted) 2022. [Q2]

    51. S. Lyndem, R. Gazi, VK Belwal, A. Bhatta, M. Jana*, A. Singha Roy*Binding of bioactive esculin and esculetin with hen egg white lysozyme: Spectroscopic and computational methods to comprehensively elucidate the binding affinities, interacting forces and conformational alterations at molecular level, Journal of Molecular Liquids, 360, 2022, 119423, DOI: https://doi.org/10.1016/j.molliq.2022.119423. [Q1]

    50. G. Kalita, S. Sarmah, A. Singha Roy, PN Chatterjee, Synthesis of 2,2-disubstituted-2H-1-benzopyrans using tetraphenylethylene-based heterogeneous acidic organocatalyst and the evaluation of their binding interaction with human serum albumin, Journal of Heterocyclic Chemistry, Accepted (2022), DOI: 10.1002/jhet.4582. [Q3]

    49. A. Sharma, S. Sarmah, A. Singha Roy, KS Ghosh*, Multispectroscopic studies on the molecular interactions between bovine globulin and borohydride capped silver nanoparticles, Luminescence, (Accepted) 2022, DOI: https://doi.org/10.1002/bio.4276 . [Q2]

    48. S. Sarmah, A. Gowsami, VK Belwal, A. Singha Roy*, Mitigation of ribose and glyoxal induced glycation, AGEs formation and aggregation of human serum albumin by citrus fruit phytochemicals naringin and naringenin: An insight into their mechanism of action, Food Research International (Accepted) 2022, DOI: https://doi.org/10.1016/j.foodres.2022.111358 [Q1]

    47. M. Haque, S. Lynda, A. Singha Roy*, Interaction properties of biosynthesized cadmium sulphide quantum dots with human serum albumin: further investigation of antibacterial activities and sensing applications, Luminescence, 2022 (accepted), DOI: 10.1002/bio.4228. [Q2]

    46. S. Das, A. Singh, S. Samanta*, A. Singha Roy*, Naturally occurring anthraquinones as potential inhibitors of SARS-CoV-2 main protease: an integrated computational study, Biologia (Accepted) 2021, DOI: https://doi.org/10.1007/s11756-021-01004-4 [Q3]

    45. S. Sarmah, S. Dhurua, V. K. Belwal, S. Lyndem, M. Jana, A. Singha Roy*, Combined spectroscopic and computational approaches for the recognition of bioactive flavonoid 6-hydroxyflavone by human serum albumin: Effects of non-enzymatic glycation in the binding, Journal of Molecular Liquids, 2021 (Accepted), DOI: 10.1016/j.molliq.2021.118288. [Q1]

    44. S. Sarmah, A. Singha Roy*, A review on prevention of glycation of proteins: Potential therapeutic substances to mitigate the severity of diabetes complications, International Journal of Biological Macromolecules, 2021 (Accepted), DOI: 10.1016/j.ijbiomac.2021.12.041. [Q1]

    43. S. Lyndem, R. Gazi, M. Jana*, V. K. Belwal, A. Singha Roy*,Molecular recognition of two bioactive coumarin derivatives 7-hydroxycoumarin and 4-methyl-7-hydroxycoumarin by hen egg white lysozyme: Exploring the binding mechanism, thermodynamic parameters and structural changes using multispectroscopic and computational approaches, Journal of Biomolecular Structure and Dynamics, 2021, (Accepted) DOI: 10.1080/07391102.2021.1995499. [Q2]

    42. M. Haque, S. Santra, D. Paul, A. Singha Roy*Binding of Water?Soluble CdSe Quantum Dots with Human Serum Albumin: Further Studies into their Effects on Dietary Polyphenol Binding and Sensing of Antibiotic Lomefloxacin, ChemistrySelect, 2021, 6, 11144-11156. https://doi.org/10.1002/slct.202102212. [Q2]

    41. K. Baruah, M. Haque, L. Langbang, S. Das, K. Aguan, A. Singha Roy*, Ocimum sanctum mediated green synthesis of silver nanoparticles: A biophysical study towards lysozyme binding and anti-bacterial activity, Journal of Molecular Liquids, 2021, 337, 116422, https://doi.org/10.1016/j.molliq.2021.116422. [Q1]

    40. S. Das, L. Langbang, M. Haque, V. Belwal, K. Aguan, A. Singha Roy*Biocompatible silver nanoparticles: An investigation into their protein binding efficacies, anti-bacterial effects and cell cytotoxicity studies, Journal of Pharmaceutical Analysis, 2020 (Accepted Article), https://doi.org/10.1016/j.jpha.2020.12.003. [Q1]

    39. S. Sarmah, S. Das, A. Singha Roy*, Protective actions of bioactive flavonoids chrysin and luteolin on the glyoxal induced formation of advanced glycation end products and aggregation of human serum albumin: iIn vitro and molecular docking analysis, International Journal of Biological Macromolecules, 165, 2020, 2275-2285. DOI: doi.org/10.1016/j.ijbiomac.2020.10.023. [Q1]

    38. S. Sarmah, S. Pahari, V. K. Belwal, M. Jana*, A. Singha Roy*, Elucidation of molecular interaction of bioactive flavonoid luteolin with human serum albumin and its glycated analogue using multi-spectroscopic and computational studies, Journal of Molecular Liquids (Accepted article), 2020, DOI: https://doi.org/10.1016/j.molliq.2020.114147. [Q1]

    37. S Das, S Sarmah, S Lyndem, A Singha Roy, An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study, Journal of Biomolecular Structure and Dynamics (Accepted article), 2020, DOI: doi.org/10.1080/07391102.2020.1763201. [Q2]

    36. S. Rana, S. Sarmah, A. Singha Roy, K. S. Ghosh*, Elucidation of molecular interactions between human ?D-crystallin and quercetin, an inhibitor against tryptophan oxidation, Journal of Biomolecular Structure and Dynamics (Accepted article), 2020, DOI: 10.1080/07391102.2020.1738960. [Q2]

    35. S. DasZ. HazarikaS. Sarmah, K. BaruahM. A. RohmanD. PaulA. N. Jha, A. Singha Roy*Exploring the interaction of bioactive kaempferol with serum albumin, lysozyme and hemoglobin: A biophysical investigation using multi-spectroscopic, docking and molecular dynamics simulation studies, Journal of Photochemistry and Photobiology B: Biology, (Accepted Article), 2020, DOI: 10.1016/j.jphotobiol.2020.111825. [Q1]

    34. S. Sarmah, S. Pahari, S. Das, V. K. Belwal, M. Jana*, A. Singha Roy*, Non-enzymatic glycation of human serum albumin modulates its binding efficacy towards bioactive flavonoid chrysin: A detailed study using multi-spectroscopic and computational methods, Journal of Biomolecular Structure and Dynamics (Accepted article), 2020, DOI: 10.1080/07391102.2019.1711196. [Q2]

    33. S. Das, S. Sarmah, Z. Hazarika, M. A. Rohman, P. Sarkhel, A. N. Jha, A. Singha Roy*, Targeting the heme protein hemoglobin by (-)-epigallocatechin gallate and the study of polyphenol-protein association using multi-spectroscopic and computational methods, Physical Chemistry Chemical Physics (Accepted article), 2020, DOI: 10.1039/C9CP05301H. [Q1]

    32. S. Das, S. Sarmah, A. Singha Roy*, Monitoring Fluorescence Emission Behaviors of Dietary Polyphenols in Serum Albumin Environment, New Journal of Chemistry (Accepted article), 2019, DOI: 10.1039/C9NJ03938D. [Q2]

    31. S. Das, S. Pahari, S. Sarmah, M .A. Rohman, D. Paul, M. Jana*, A. Singha Roy*, Lysozyme-luteolin binding: Molecular insights into the complexation process and the inhibitory effects of luteolin towards protein modification, Physical Chemistry Chemical Physics, 2019, 21, 12649-12666. DOI: 10.1039/C9CP01128E. [Q1]

    30. S. Das, S. Santra, M. A. Rohman, M. Ray, M. Jana*, A. Singha Roy*, An Insight into the Binding of 6-Hydroxyflavone with Hen Egg White Lysozyme: A Combined Approach of Multi-Spectroscopic and Computational Studies, Journal of Biomolecular Structure and Dynamics, 2018, 37, 4019-4034. DOI: 10.1080/07391102.2018.1535451. [Q2]

    29. S. Das, P. Khanikar, Z. Hazarika, M. A. Rohman, A. Uzir, A. N. Jha*, A. Singha Roy*, Deciphering the Interaction of 5, 7-Dihydroxyflavone with Hen-Egg-White Lysozyme through Multispectroscopic and Molecular Dynamics Simulation Approaches, ChemistrySelect, 2018, 3, 4911-4922. [Q2]

    28. S. Das, N. Bora, M. A. Rohman, R. Sharma, A. N. Jha*, A. Singha Roy*, Molecular recognition of bio-active flavonoids quercetin and rutin by bovine hemoglobin: An overview of the binding mechanism, thermodynamics and structural aspects through multi-spectroscopic and molecular dynamics simulation studies, Physical Chemistry Chemical Physics, 2018. 20, 21668-21684. [Q1]

    27. S. Das, A. Karn, R. Sharma, M.A. Rohman, S. Koley, P. Ghosh, A. Singha Roy*, Characterization of non-covalent binding of 6-hydroxyflavone and 5,7-dihydroxyflavone with bovine hemoglobin: Multi-spectroscopic and molecular docking analyses, Journal of Photochemistry and Photobiology B: Biology, 2018, 178, 40-52. [Q1]

    26. S. Das, P. Ghosh, S. Koley, A. Singha Roy*, Binding of naringin and naringenin with hen egg white lysozyme: A spectroscopic investigation and molecular docking study, Spectrochimica Acta A: Molecular and Biomolecular Spectroscopy, 2018, 192, 211-221. [Q2]

    25. S. Das, M. A. Rohman, A. Singha Roy*,, Exploring the non-covalent binding behaviours of 7-hydroxyflavone and 3-hydroxyflavone with hen egg white lysozyme: Multi-spectroscopic and molecular docking perspectives, Journal of Photochemistry & Photobiology B: Biology, 2018, 180, 25-38. [Q1]

    Earlier Publications

    24. A. Singha Roy*, P. Ghosh, Characterization of the binding of flavanone hesperetin with chicken egg lysozyme using spectroscopic techniques: effect of pH on the binding, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2016, 84, 21-34. [Q3]

    23. P. Ghosh, A. Singha Roy, S. Chaudhury, S. Jana, K. Chaudhury, S. Dasgupta, Preparation of albumin based nanoparticles for delivery of fisetin and evaluation of its cytotoxic activity, International Journal of Biological Macromolecules, 2016, 86, 408-417. [Q1]

    22. A. Singha Roy*, D. R. Tripathy, S. Samanta, S. K. Ghosh, S.Dasgupta, DNA damaging, cell cytotoxicity and serum albumin binding efficacy of the rutin-Cu(II) complex, Molecular BioSystems, 2016, 12, 1687-1701.

    21. A. Singha Roy*, A. Kumar Dinda, N. K. Pandey, S. Dasgupta, Effects of urea, metal ions and surfactants on the binding of baicalein with bovine serum albumin, Journal of Pharmaceutical Analysis, 2016, 6, 256-267. [Q1]

    20. A. Singha Roy*, P. Ghosh, Swagata Dasgupta, Glycation of human serum albumin affects its binding affinity towards (-)-epigallocatechin gallate, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2016, 85, 193-202. [Q3]

    19. A. Singha Roy*, S. Samanta, P. Ghosh, D. R. Tripathy, S. Ghosh, S. Dasgupta, Cell cytotoxicity and serum albumin binding capacity of the morin-Cu(II) complex and its effect on deoxyribonucleic acid, Molecular BioSystems, 2016, 12, 2818-2833.

    18. P. Ghosh, S. Bag, A. Singha Roy, E. Subramani, K. Chaudhury, S. Dasgupta, Solubility enhancement of morin and epicatechin through encapsulation in albumin based nanoparticulate system and their anticancer activity against the MDA-MB-468 breast cancer cell line, RSC Advances, 2016, 6, 101415-101429. [Q2]

    17. A. Singha Roy*, J. Utreja, S. Badhei, Characterization of the binding of fisetin and morin with chicken egg lysozyme using spectroscopic and molecular docking methods, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2015, 81, 385-394. [Q3]

    16. A. Singha Roy*, P. Ghosh, S. Dasgupta, Glycation of human serum albumin alters its binding efficacy towards the dietary polyphenols: A comparative approach, Journal of Biomolecular Structure and Dynamics, 2015, 34, 1911-1985. [Q2]

    15. A. Singha Roy, A. K. Dinda, S. Chaudhury, S. Dasgupta, Binding of antioxidant flavonol morin to the native state of bovine serum albumin: Effects of urea and metal ions on the binding, Journal of Luminescence, 2014, 45, 741-751. [Q2]

    14. A. Singha Roy, K. S. Ghosh, S. Dasgupta, An investigation into the altered binding mode of green tea polyphenols with human serum albumin on complexation with Copper, Journal of Biomolecular Structure and Dynamics, 2013, 31, 1191-1206. [Q2]

    13. A. Singha Roy, N. K. Pandey, S. Dasgupta, Preferential binding of fisetin to the native state of bovine serum albumin: Spectroscopic and docking studies, Molecular Biology Reports, 2013, 40, 3239-3253. [Q2]

    12. A. Singha Roy, D. R. Tripathy, A. Chatterjee, S. Dasgupta, The influence of Common Metal Ions on the Interactions of the Isoflavone Genistein with Bovine Serum Albumin, Spectrochimica Acta A: Molecular and Biomolecular Spectroscopy, 2013, 102, 393-402. [Q2]

    11. M. Mukherjee, P. Saha Sardar, Shyamal Kr. Ghorai, Swarna Kamal Samanta, Atanu Singha Roy, Swagata Dasgupta, Sanjib Ghosh, A Comparative Study of Interaction of Tetracycline with Several Proteins Using Time Resolved Anisotropy, Phosphorescence, Docking and FRET, PLoS ONE, 2013, 8, e60940. [Q1]

    10. S. Ghosh; N. K. Pandey; A. Singha Roy; D. R. Tripathy; A. K. Dinda; S. Dasgupta, Prolonged glycation of hen egg white lysozyme generates non amyloidal structures, PLoS ONE, 2013, 8, e74336. [Q1]

    9. D. R. Tripathy, N. K. Pandey, A. K. Dinda, S. Ghosh, A. Singha Roy, S. Dasgupta, An insight into ribonucleolytic and antiangiogenic activity of buffalo lactoferrin, Journal of Biomolecular Structure and Dynamics, 2013, 33,184-189. [Q2]

    8. A. Singha Roy, A. K. Dinda, S. Dasgupta, Study of the interaction between fisetin and human serum albumin: A biophysical approach, Protein and Peptide Letters, 2012, 19, 604-615. [Q3]

    7. D. Roy, S. Dutta, S. S. Maity, S. Ghosh, A. Singha Roy, K. S. Ghosh, S. Dasgupta, Spectroscopic and Docking Studies of the Binding of Two Stereoisomeric Antioxidant Catechins to Serum Albumins, Journal of Luminescence, 2012, 132, 1364-1375. [Q2]

    6. A. Singha Roy, D. R. Tripathy, A. K. Ghosh, S. Dasgupta, An alternate mode of binding of the polyphenol quercetin with serum albumins when complexed with Cu(II), Journal of Luminescence, 2012, 132, 2943-2951. [Q2] 

    5. M. Mukherjee, P. Saha Sardar, S.Kr. Ghosh, S. Kamal Samanta, A. Singha Roy, S. Dasgupta, S. Ghosh, Interaction of Multitryptophan Protein with Drug: An Insight into the Binding Mechanism and the Binding Domain by Time Resolved Emission, Anisotropy, Phosphorescence and Docking, Journal of Photochemistry and Photobiology B: Biology, 2012, 115, 93-104. [Q1] 

    4. Q. Saquib, A. A. Al-Khedhairy, M. A. Siddiqui, A. Singha Roy, S. Dasgupta, J. Musarrat, Preferential binding of insecticide phorate with sub-domain IIA of human serum albumin induces protein damage and its toxicological significance, Food and Chemical Toxicology, 2011, 49, 1787-1795. [Q1]

    3. D. R. Tripathy, A. Singha Roy, S.Dasgupta, Complex formation of rutin and quercetin with copper alters the mode of inhibition of Ribonuclease A, FEBS Letters, 2011, 585, 3270-3276. [Q1]

    2. A. Singha Roy, D. R. Tripathy, A. Chatterjee, S.Dasgupta, A spectroscopic study of the interaction of the antioxidant naringin with bovine serum albumin, Journal of Biophysical Chemistry, 2010, 1, 141-152. 

    1. B. Chakraborty, A. Singha Roy, S. Dasgupta, S. Basu, Magnetic Field Effect Corroborated with Docking Study to Explore Photoinduced Electron Transfer in Drug Protein Interaction, Journal of Physical Chemistry A, 2010, 114, 13313-13325.[Q2]

    Administrative Responsibilities

        1. Chairman (Central Instrumentation Facility, CIF): February 2021-till date.
        2. President, Student Activity Centre: July 2023-
        3. Coordinator from NIT Meghalaya: Unnat Bharat Abhiyan
        4. Chief warden: July 2021-June 2023.
        5. Head of the Department: July 2018-June 2021.
        6. Member: Medical Facilitation Committee (2019-2021)
        7. Convener: Hostel Patrolling Committee (2019-2020)
        8. Member: Medical and COVID Response Committee (2021-2023)
        9. Member: Library Committee (Dept. Level)
        10. Member: Routine Committee (Dept. Level)
        11. Member: Examination Cell (2018-2021)
        12. Faculty-in-Charge: Sports Committee of NIT Meghalaya (2017-2018)
        13. Member: M.Sc. admission Committee (2016)
        14. Member: Academic Audit Committee (2016)
        15. Member: NSS Committee (24-9-2015 to 31-01-2018)
        16. Member: Institute Ranking Committee (2016-2017)

    Sponsored Projects

    Sl No.

    Title of Project

    PI

    CO-PI

    Funding Agency (Category)

    Sanctioned Amount

    StartYr - EndYr (Duration)

    Status

    Project Type

    1

    An investigation into the molecular interaction of dietary polyphenols with hen egg white lysozyme using biophysical techniques

    Dr. Atanu Singha Roy

    NA

    SERB, DST (ECR)

    36,69,000

    2016-2019

    Completed

    Sponsored

    2

    Molecular interactions of the antioxidant polyphenols and their copper complexes with human serum albumin and its glycated analogues

    Dr. Atanu Singha Roy

    NA

    CSIR (EMR)

    6,90,000

    2017-2020

    Completed

    Sponsored

    3

    Synthesis of biocompatible silver and gold nanoparticles using dietary polyphenols as reducing agents: Further investigation into their binding efficacies with the carrier proteins, biomolecular detections, anti-bacterial properties and cell cytotoxicity

    Dr. Atanu Singha Roy

    NS

    SERB-DST (CRG)

    25,12,400

    2020-2023

    Completed (on 30-6-23) 

    Sponsored

    Ph.D. Students

    1. Current Members
    2. Mr. Mahabul Haque (Research area: Biological applications of water soluble luminescent quantum dots, 2019-Present).
    3. Ms. Sona Lyndem (Research area: Binding of bio-active molecules with the carrier proteins, 2020-Present).
    4. Ms. Kakali Baruah (Research area: Bio-compatible silver and gold nano-particles: binding with the carrier proteins and applications, 2020-present).
    5. Ms. Sadia Nudrat (Research area: Interaction studies of bioactive phytochemicals with proteins, 2022-present).
    6. Ms. Sana Quraishi (Researh area: Synthesis of biologically active compounds and their interactions with the proteins, 2022-present).
    7. Mr. Amarjyoti Mondal (Research area: Protein/Peptide/DNA-based hydrogel for biological applications), 2022-present.
    8. Mr. Surendra Nath Barman (Research area: CNTs for biological applications), 2023-present.
    9. Mr. Mitul Kalita (Research area: Quantum dot based LEDs), 2023-present.

    Conference/Symposium/Workshop/Seminar Organised

    Symposium and Conference

    Sl No.TitleSponsorsNational/International    Duration              Role Played
    1Recent Trends in Chemical SciencesNEC, SERB-DST, AMD               National October 12-13, 2017 Organizing Secretary     (Sub-Committee)
    2   Recent Advances in Chemistry   NEC, SERB, CSIR, TEQIP-III      National        October 14-15, 2019    Convener

    Conference/Workshop/Seminar Attended

      Conference and Symposium

      1. One day Symposium in Chemistry, IIT Kharagpur, November 2008.
      2. 12th CRSI Symposium in Chemistry, IICT Hyderabad, February 5-7, 2010.
      3. Diamond Jubilee Symposium on Recent Trends in Chemistry, IIT Kharagpur, October 21-23, 2011.
      4. International symposium on Recent Trends on Research in Chemistry, Midnapore College, Vidyasagar University, October 31 - November 1, 2011.
      5. International Symposium on Chemistry and Complexity, IACS Kolkata, December 6-8, 2011.
      6. 15th CRSI Symposium in Chemistry, Banaras Hindu University, February 1-3, 2013.
      7. Exploring Basic and Applied Sciences for Next Generation Frontiers, Lovely Professional University, November 14-15, 2014 (Oral Presentation).
      8. National Symposium on Emerging Trends in Chemistry, North Eastern Hill University Shillong, March 28-29, 2016.
      9. National Conference of Chemical Physics, Assam University Silchar, March 20-21, 2017 (Oral Presentation).
      10. Recent Trends in Chemical Sciences, NIT Meghalaya, October 12-13, 2017.
      11. National Seminar on Contemporary Challenges in Chemistry (NSC3-2018), North Eastern Hill University Shillong, November 20-21, 2018 (Invited Research Talk).

      Workshop

      1. Workshop on Biocalorimetry, IICB Kolkata & SINP Kolkata, February 4-6, 2009.
      2. Workshop on Biophotonics - A Multidisciplinary Approach, NIT Meghalaya, November 18-19, 2016.
      3. Accreditation and Transformation of Technical Education to OBE, NIT Meghalaya, January 22-23, 2016.
      4. Workshop on creation and promotion of online teaching resources: A national initiative, NIT Meghalaya, June 5, 2017.

      Professional Membership

      1. Chemical Research Society of India (CRSI, Life Member)
      2. Indian Chemical Society (Life Member)
      3. The Society of Biological Chemists, India (Life Member)
      4. Indian Biophysical Society (Life Member)
      5. Fluorescence Society India (Life Member)
      6. The Indian Science Congress Association (Life Member)
      7. Indian Peptide Society (Life Member)
      8. Indian Photobiology Society (Life Member)

      Awards and Recognitions

      1. National Scholarship Examination for Secondary Stage 1999 (Gov't of West Bengal).

      2. CSIR-NET JRF Fellowship 2007.

      3. GATE 2007.

      4. SERB Early Career Research (ECR) Project Award 2016.

      5. Faculty Award for Continuous Support to NIT Meghalaya in activities beyond normal teaching and research (2022).

      6. Recognized as Top 2% Scientist by Stanford University 2023.

      Book Chapter(s)

      1. Atanu Singha Roy, Sharat Sarmah and Sourav Das, Chapter Title: Effects of Glycation on Serum Albumins, 2021 (Accepted), Nova Science Publishers, Inc. USA (ISBN: 978-1-53619-176-9) [Book Title: A closer look at glycation].

      2. Sona Lyndem, Sharat Sarmah, Sourav Das, Atanu Singha Roy, Chapter Title: Coumarin derivatives: Biomedicinal properties and interactions with carrier proteins, 2021 (Accepted), Elsevier (ISBN: 9780323910972[Book Title: Studies in Natural Product Chemistry, volume 73, chapter no. 6].

      Facilities at PI's Laboratory

      1. Spectrofluorimeter with Peltier attachment (Make: Agilent Technologies, Funded by SERB-ECR)
      2. Research Centrifuge (Make: Remi, PR-24)
      3. Bacteriological Incubator (Make: Biocoction Manufacturing Pvt. Ltd.)

      Reviewer of the journals

      The Journal of Physical Chemistry Letters (ACS Publications), ACS Food Science & Technology, Colloids and Surfaces B: Biointerfaces (Elsevier), ACS Omega (ACS Publications), Journal of Asian Natural Products Research (Taylor and Francis), Luminescence (Wiley), Journal of Molecular Liquids (Elsevier), Journal of Biomolecular Structure and Dynamics (Taylor and Francis), RSC Advances (RSC), Physical Chemistry Chemical Physics (RSC), Indian Journal of Pharmaceutical Sciences, Journal of Photochemistry and Photobiology B: Biology (Elsevier), Journal of Luminescence (Elsevier), Journal of Advanced Research in Biotechnology (Symbiosis Group), Journal of Medicinal Chemistry and Drug Design (Sci Forschen Inc. USA), Spectrochimica Acta A: Molecular and Biomolecular Spectroscopy (Elsevier), Journal of Agricultural and Food Chemistry (ACS Publications), Food Hydrocolloids (Elsevier), Food and Function (RSC), Journal of King Saud University (Elsevier), Scientific Reports (Nature Research), Chemical Data Collections (Elsevier), Food Chemistry + OA Mirror (Elsevier), Current Organic Synthesis (Bentham Science Publishers), Letters in Drug Design and Development (Bentham Science Publishers), Spectroscopy Letters (Taylor and Francis), BMC Genomics (BMC Series, Springer Nature), Frontiers in Nutrition (Frontiers), Food Chemistry (Elsevier), Journal of Indian Chemical Society, International Journal of Food Science and Technology (Wiley), Amino Acids (Springerlink), Food Biophysics (Springerlink), Nano Biomedicine and Engineering (Shanghai Jiao Tong University Press), Analytical Methods (RSC)

      Collaborators

      1. Dr. Anupam Nath Jha, Department of Molecular Biology and Biotechnology, Tezpur University.

      2. Dr. Madhurima Jana, Department of Chemistry, NIT Rourkela.

      3. Professor K. Aguan, Department of Biotechnology & Bioinformatics, North Eastern Hill University Shillong.

      4. Dr. Sudipta Koley (Department of Physics, Amity University, Kolkata).


      Lab News

      1. Congratulations to Sourav Das and Sharat for their recent publication in NJC:
      2. S. Das, S. Sarmah, A. Singha Roy*, Monitoring Fluorescence Emission Behaviors of Dietary Polyphenols in Serum Albumin Environment, New Journal of Chemistry (Accepted article), 2019, DOI: 10.1039/C9NJ03938D.
      3. Congratulations to Sourav Das for his recent achievement: Best Poster Award at the National Conference on Recent Trends in Chemistry (RAC) organized by the Department of Chemistry, NIT Meghalaya during October 14-15, 2019.
      4. Congratulations to Sourav Das for his recent publication in PCCP. [S. Das, S. Sarmah, Z. Hazarika, M. A. Rohman, P. Sarkhel, A. N. Jha, A. Singha Roy*, Targeting the heme protein hemoglobin by (-)-epigallocatechin gallate and the study of polyphenol-protein association using multi-spectroscopic and molecular docking methods, Physical Chemistry Chemical Physics (Accepted article), 2020, DOI: 10.1039/C9CP05301H.]
      5. Congratulations to Sharat Sarmah for his recent publication in JBSD.
        [S. Sarmah, S. Pahari, S. Das, V. K. Belwal, M. Jana*, A. Singha Roy*, Non-enzymatic glycation of human serum albumin modulates its binding efficacy towards bioactive flavonoid chrysin: A detailed study using multi-spectroscopic and computational methods, Journal of Biomolecular Structure and Dynamics (Accepted article), 2020, DOI: 10.1080/07391102.2019.1711196.]
      6. Ms. Sona Lyndem joined the group for Ph.D. programme (January 2020), welcome!
      7. Congratulations to Sourav Das for his recent publication in Journal of Photochemistry and Photobiology B: Biology. [S. Das, Z. Hazarika, S. Sarmah, K. Baruah, M. A. Rohman, D. Paul, A. N. Jha, A. Singha Roy, Exploring the interaction of bioactive kaempferol with serum albumin, lysozyme and hemoglobin: A biophysical investigation using multi-spectroscopic, docking and molecular dynamics simulation studies, Journal of Photochemistry and Photobiology B: Biology, (Accepted Article), 2020, DOI: 10.1016/j.jphotobiol.2020.111825.]
      8. Congratulations to Sourav Das for his recent achievement: Institute Best Research Award (1st Research Conclave 2020 of NIT Meghalaya, date: 28-02-2020).
      9. Ms. Kakali Baruah joined the group for Ph.D. programme (August 2020), welcome!
      10. Congratulations to Sourav Das for receiving research excellence award (in oral presentation category) in RACMS 2020 (Indian Chemical Society).
      11. Sourav Das successfully defended his Ph.D. Oral Viva-voce Seminar on 15-03-2021. Congratulations!
      12. Congratulations to Mahabul for his first paper in ChemistrySelect.
      13. Congratulations to Sona Lyndem for her first paper in JBSD.
      14. Congratulations to Mahabul for his recent article in Luminescence.
      15. Amarjyoti (NIT Meghalaya) and Surendra Nath (NIT Sikkim) have recently joined our group, Welcome!
      16. Congratulations to Mahabul for his recent paper in J. Mat. Chem. B.
      17. Congratulations to Kakali for her recent paper in Spectrochimica Acta A.
      18. Congratulations to Sona  for the best poster award in ETCS 2023 (NEHU Shillong).
      19. Congratulations to Kakali for the best poster award in ISMC 2023 (BARC).
      20. Congratulations to Sadia for her first paper in ACS Food Science and Technology.
      21. Congratulations to Dr. Sharat for receiving DBT-RA Fellowship 2023.
      22. Congratulations to Sona for her recent paper in New Journal of Chemistry (In-vitro Interactions of Esculin and Esculetin with Bovine Hemoglobin Alter its Structure and Inhibit Aggregation: Insights from Spectroscopic and Computational Studies).
      23. Mitul Kalita joined the group as Research Scholar (Autumn 2023). Welcome!
      24. ASR has been recognized as the Top 2% Scientist by Stanford University 2023.
      25. Congratulations to Kakali for the best poster award in Physical Chemistry Symposium (SoPhyC-2023) at IIT Kanpur.
      26. Congratulations Sana for her recent paper in International Journal of Biological Macromolecules (IJBM).
      27. Congratulations Kakali for her recent paper in Langmuir.
      28. Congratulations to Sadia for her first paper in ACS Food Science and Technology.

      Group Alumni

           Ph.D. Student
      • Dr. Sourav Das (Thesis Title: An investigation into the biological interactions of dietary polyphenols with the targets: Binding properties and the inhibitory potential of the polyphenols towards protein modification, 2016-2021) [Former: DBT-RA, IISC Bangalore, Presently: Asst. Prof. RGU Guwahati]
      • Dr. Sharat Sarmah (Thesis Title: Exploring the interactions of natural bioactive compounds with the carrier proteins: Impacts of glycation, metal ion and binding with DNA, 2018-2023) [DBT-RA, IISC Bangalore].
      • Past Summer/Winter Project Students/Virtual Internship
      • Ms. Collinica Camillie Syiemlieh (Pondicherry University), June-July 2018.
      • Mr. Sharat Sarmah (NIT Meghalaya), June-July 2016.
      • Ms. Gitumoni Kalita (NIT Meghalaya), June-July 2016.
      • Mr. Subhankar Barman (NIT Meghalaya), June-July 2016.
      • Ms. Yogita Basumatary (USTM Meghalaya), January-February 2019.
      • Ms. Safety Engel Lyngdoh Kynshi (USTM Meghalaya),  January-February 2019.
      • Ms. Pallavi Sarkhel (BIT Mesra, Jharkhand), May-June 2019.
      • Ms. Sagarika Roy (University of Hyderabad), Virtual Internship, Young Academy of India, July-September 2020.
      • Mr. Shivam Khare (Thapar Institute of Engineering and Technology, Patiala), May-July 2022.
      • Mr. I Karan Kumar (NIT Manipur), June-July 2023.
      • Ms. Pelesi Tayang (Rajiv Gandhi University, Itanagar, Arunachal Pradesh), June-July 2023.



      • Past M.Sc. Project Students
      • Ms. Alka Karn (2016-2017) [Pursuing Ph.D.: IIT Kanpur]
      • Ms. Mahuah Ray (2016-2017).
      • Mr. Raju Sharma (2017-2018). 
      • Ms. Antara Uzir (2017-2018).
      • Ms. Ankita Agarwal (2018-2019) [Pursuing Ph.D.: NIT Meghalaya]
      • Ms. Kakali Baruah (2018-2019) [Pursuing Ph.D.: NIT Meghalaya]
      • Mr. Mahabul Haque (2018-2019) [Pursuing Ph.D.: NIT Meghalaya]
      • Mr. Sujan Santra (2018-2020) [Pursuing Ph.D.: IIT Kharagpur]
      • Mr. Vikash Singh Kharesiya (2018-2020)
      • Ms. Archita Goswami (2019-2021) [Pursuing Ph.D.: Tezpur University]
      • Ms. Soni Moni Das (2019-2021) [Pursuing Ph.D.: IIT Delhi]
      • Mr. Thaha Ramees (2019-2021)
      • Mr. Athul P (2020-2022)
      • Mr. Mitul Kalita (2020-2022) [Pursuing Ph.D at NIT Meghalaya]
      • Jintu Chutia (2022-2023)

      • Aneesha SL (2022-2023) [Pursuing Ph.D. in Hokkaido University, Japan]

      • Mrinmoyee Saikia (2022-2023)

      • Somya Sharma (2022-2023)

      Invited Talks (as resource person)

        1. Invited talk in the National Seminar on Contemporary Challenges in Chemistry (NSC3-2018), North Eastern Hill University Shillong, November 20-21, 2018 (Jointly Organized by North Eastern Hill University Shillong and SNBCBS Kolkata to Commemorate 125th Birth Anniversary of Professor S. N. Bose).
        2. Special Summer School in Basic Sciences and Technology (8th – 21st July 2019), North Eastern Hill University Shillong, July 18, 2019, Organized by UGC-HRDC NEHU Shillong.
          1. Refresher Course in Chemistry, 8th November 2022, North Eastern Hill University, Organized by UGC-HRDC NEHU Shillong.
            1. IUPAC - Global Women Breakfast 2023 Lecture at Synod College (Shillong), February 14, 2023.
              1. Refresher Course in Chemistry, 8th August 2023, North Eastern Hill University, Organized by UGC-HRDC NEHU Shillong.
                1. Invited Talk in the Physical Chemistry Symposium 2023 (inaugural conference of SoPhyC-2023) at IIT Kanpur during 28-31st October 2023.
                2. Invited Short Talk in 92nd Meeting of Society of Biological Chemist at BITS-Goa during 18-20th December 2023.


                Available Positions

                The research group is looking for motivated and dynamic students to be involved in research areas of Experimental Biophysical Chemistry. The students qualified in GATE and NET examinations may apply for a Ph.D. position. Available position: 02 for Ph.D.